Postmortem evidence of disseminated Zika virus infection in an adult patient

Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 20...

Full description

Saved in:
Bibliographic Details
Main Authors: Rajahram, Giri Shan, Hale, Gillian, Bhatnagar, Julu, Hiu, Jessie, Thayan, Ravindran, William, Timothy, Wong, Kum Thong, Tambyah, Paul Anantharajah, Yeo, Tsin Wen
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/105746
http://hdl.handle.net/10220/48735
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-105746
record_format dspace
spelling sg-ntu-dr.10356-1057462020-11-01T05:21:31Z Postmortem evidence of disseminated Zika virus infection in an adult patient Rajahram, Giri Shan Hale, Gillian Bhatnagar, Julu Hiu, Jessie Thayan, Ravindran William, Timothy Wong, Kum Thong Tambyah, Paul Anantharajah Yeo, Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) Viruses ZIKV Infections DRNTU::Science::Medicine Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 2009). In adults, fatal and non-fatal neurological complications have been reported, including encephalitis and Guillain–Barré syndrome (Soares et al., 2016, Oehler et al., 2014). Non-neurological fatalities have also been reported sporadically in patients from Latin America, who have presented with an acute febrile illness and multi-organ failure (Sarmiento-Ospina et al., 2016, Zonneveld et al., 2016). This report describes the clinical features and postmortem findings of a 61-year-old Malaysian male with co-morbidities, who had a fatal outcome subsequent to an acute febrile and rash illness, with pre- and postmortem evidence of ZIKV infection. Published version 2019-06-13T08:06:36Z 2019-12-06T21:57:08Z 2019-06-13T08:06:36Z 2019-12-06T21:57:08Z 2019 Journal Article Rajahram, G. S., Hale, G., Bhatnagar, J., Hiu, J., Thayan, R., William, T., . . . Yeo, T. W. (2019). Postmortem evidence of disseminated Zika virus infection in an adult patient. International Journal of Infectious Diseases, 83, 163-166. doi:10.1016/j.ijid.2019.01.047 1201-9712 https://hdl.handle.net/10356/105746 http://hdl.handle.net/10220/48735 10.1016/j.ijid.2019.01.047 en International Journal of Infectious Diseases © 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 4 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Viruses
ZIKV Infections
DRNTU::Science::Medicine
spellingShingle Viruses
ZIKV Infections
DRNTU::Science::Medicine
Rajahram, Giri Shan
Hale, Gillian
Bhatnagar, Julu
Hiu, Jessie
Thayan, Ravindran
William, Timothy
Wong, Kum Thong
Tambyah, Paul Anantharajah
Yeo, Tsin Wen
Postmortem evidence of disseminated Zika virus infection in an adult patient
description Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 2009). In adults, fatal and non-fatal neurological complications have been reported, including encephalitis and Guillain–Barré syndrome (Soares et al., 2016, Oehler et al., 2014). Non-neurological fatalities have also been reported sporadically in patients from Latin America, who have presented with an acute febrile illness and multi-organ failure (Sarmiento-Ospina et al., 2016, Zonneveld et al., 2016). This report describes the clinical features and postmortem findings of a 61-year-old Malaysian male with co-morbidities, who had a fatal outcome subsequent to an acute febrile and rash illness, with pre- and postmortem evidence of ZIKV infection.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Rajahram, Giri Shan
Hale, Gillian
Bhatnagar, Julu
Hiu, Jessie
Thayan, Ravindran
William, Timothy
Wong, Kum Thong
Tambyah, Paul Anantharajah
Yeo, Tsin Wen
format Article
author Rajahram, Giri Shan
Hale, Gillian
Bhatnagar, Julu
Hiu, Jessie
Thayan, Ravindran
William, Timothy
Wong, Kum Thong
Tambyah, Paul Anantharajah
Yeo, Tsin Wen
author_sort Rajahram, Giri Shan
title Postmortem evidence of disseminated Zika virus infection in an adult patient
title_short Postmortem evidence of disseminated Zika virus infection in an adult patient
title_full Postmortem evidence of disseminated Zika virus infection in an adult patient
title_fullStr Postmortem evidence of disseminated Zika virus infection in an adult patient
title_full_unstemmed Postmortem evidence of disseminated Zika virus infection in an adult patient
title_sort postmortem evidence of disseminated zika virus infection in an adult patient
publishDate 2019
url https://hdl.handle.net/10356/105746
http://hdl.handle.net/10220/48735
_version_ 1683493804306333696