Rhodamine-modified upconversion nanophosphors for ratiometric detection of hypochlorous acid in aqueous solution and living cells

• Main Authors: Zhou, Yi, Pei, Wenbo, Wang, Chenyuan, Zhu, Jixin, Wu, Jiansheng, Yan, Qinyu, Huang, Ling, Huang, Wei, Yao, Cheng, Loo, Joachim Say Chye, Zhang, Qichun
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine::Biosensors
• Online Access: https://hdl.handle.net/10356/105768; http://hdl.handle.net/10220/20910
• Institution: Nanyang Technological University

Hypochlorous acid (HOCl), a reactive oxygen species (ROS) produced by myeloperoxidase (MPO) enzyme-mediated peroxidation of chloride ions, acts as a key microbicidal agent in immune systems. However, misregulated production of HOCl could damage host tissues and cause many inflammation-related diseas...