Effect of A22 on the conformation of bacterial actin MreB

• Main Authors: Awuni, Elvis, Mu, Yuguang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Molecular Dynamics; Simulations; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105780; http://hdl.handle.net/10220/48773
• Institution: Nanyang Technological University

The mechanism of the antibiotic molecule A22 is yet to be clearly understood. In a previous study, we carried out molecular dynamics simulations of a monomer of the bacterial actin-like MreB in complex with different nucleotides and A22, and suggested that A22 impedes the release of Pi from the acti...