Type 1 conventional CD103+ dendritic cells control effector CD8+ T cell migration, survival, and memory responses during influenza infection

• Main Authors: Ng, See Liang, Teo, Yi Juan, Setiagani, Yolanda Aphrilia, Karjalainen, Klaus, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Influenza; DRNTU::Science::Biological sciences; Dendritic Cell
• Online Access: https://hdl.handle.net/10356/105816; http://hdl.handle.net/10220/48772
• Institution: Nanyang Technological University

Type 1 conventional CD103+ dendritic cells (cDC1) contribute significantly to the cytotoxic T lymphocyte (CTL) response during influenza virus infection; however, the mechanisms by which cDC1s promote CTL recruitment and viral clearance are unclear. We demonstrate that cDC1 ablation leads to a defic...