Discovery of novel triazole-containing pyrazole ester derivatives as potential antibacterial agents

• Main Authors: Chu, Ming-Jie, Liu, Hao, Cheng, Xiang, Mo, Kai, Wang, Li, Tang, Feng, Lv, Xian-Hai, Wang, Wei, Ren, Zi-Li
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Pyrazole; DRNTU::Science::Chemistry; Triazole
• Online Access: https://hdl.handle.net/10356/105831; http://hdl.handle.net/10220/48767
• Institution: Nanyang Technological University

To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the most potent antibacterial activity with Minimum inhib...