Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin

• Main Authors: Graefe-Mody, Ulrike, Boehm, Bernhard O., Mark, Michael, Zimdahl, Heike, Ittrich, Carina, Woerle, Hans-Juergen, Dugi, Klaus A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/105881; http://hdl.handle.net/10220/20950
• Institution: Nanyang Technological University

Aims/hypothesis Individuals carrying variants of the transcription factor 7-like 2 gene (TCF7L2) are at increased risk for type 2 diabetes. These metabolic genetic risk factors have been linked to diminished pancreatic islet-cell responsiveness to incretins, thus pharmacological interventions aim...