TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2

TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2

Naive CD4+ T lymphocytes differentiate into various Th cell subsets following TCR binding to microbial peptide:MHC class II (p:MHCII) complexes on dendritic cells (DCs). The affinity of the TCR interaction with p:MHCII plays a role in Th differentiation by mechanisms that are not completely understo...

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Bibliographic Details
Main Authors: Kotov, Dmitri I., Mitchell, Jason S., Pengo, Thomas, Ruedl, Christiane, Way, Sing Sing, Langlois, Ryan A., Fife, Brian T., Jenkins, Marc K.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
DRNTU::Science::Biological sciences
TCR Affinity
Th Cell
Online Access:https://hdl.handle.net/10356/105928
http://hdl.handle.net/10220/48821
http://dx.doi.org/10.4049/jimmunol.1801609
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/105928
http://hdl.handle.net/10220/48821
http://dx.doi.org/10.4049/jimmunol.1801609

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