Contrasting effects of vasculogenic induction upon biaxial bioreactor stimulation of mesenchymal stem cells and endothelial progenitor cells cocultures in three-dimensional scaffolds under in vitro and in vivo paradigms for vascularized bone tissue engineering

• Main Authors: Chan, Jerry Kok Yen, Liu, Yuchun, Teoh, Swee-Hin, Chong, Mark S. K., Yeow, Chen-Hua, Kamm, Roger D., Choolani, Mahesh
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine::Tissue engineering
• Online Access: https://hdl.handle.net/10356/106134; http://hdl.handle.net/10220/23986
• Institution: Nanyang Technological University

Clinical translation of bone tissue engineering approaches for fracture repair has been hampered by inadequate vascularization required for maintaining cell survival, skeletal regeneration, and remodeling. The potential of vasculature formation within tissue-engineered grafts depends on various fact...