Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities

Tianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions...

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Main Authors: Mishra, Manisha, Sze, Siu Kwan, Hu, Jiang-Miao, Feng, Zhi Wei, Heese, Klaus, Ramachandran, Umamaheswari, Sundaramurthi, Husvinee, Manavalan, Arulmani
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2014
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Online Access:https://hdl.handle.net/10356/106235
http://hdl.handle.net/10220/23952
http://www.ijbmb.org/1205001A.html
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1062352020-09-26T21:55:22Z Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities Mishra, Manisha Sze, Siu Kwan Hu, Jiang-Miao Feng, Zhi Wei Heese, Klaus Ramachandran, Umamaheswari Sundaramurthi, Husvinee Manavalan, Arulmani School of Biological Sciences Institute of Advanced Studies DRNTU::Science::Biological sciences::Biochemistry Tianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions of tianma thus led us to investigate its specific effects on neuronal signalling. Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach. We identified 2178 proteins, out of which 74 were found to be altered upon tianma treatment in differentiated mouse neuronal N2a cells. Based on the observed data obtained, we hypothesize that tianma could promote neuro-regenerative processes by inhibiting stress-related proteins and mobilizing neuroprotective genes such as Nxn, Dbnl, Mobkl3, Clic4, Mki67 and Bax with various regenerative modalities and capacities related to neuro-synaptic plasticity. Published version 2014-10-01T09:15:10Z 2019-12-06T22:07:04Z 2014-10-01T09:15:10Z 2019-12-06T22:07:04Z 2012 2012 Journal Article Manavalan, A., Ramachandran, U., Sundaramurthi, H., Mishra, M., Sze, S. K., Hu, J.-M., et al. (2012). Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. International journal of biochemistry and molecular biology, 3(2), 219-241. 2152-4114 https://hdl.handle.net/10356/106235 http://hdl.handle.net/10220/23952 http://www.ijbmb.org/1205001A.html en International journal of biochemistry and molecular biology © 2012 e-Century Publishing. This paper was published in International Journal of Biochemistry and Molecular Biology and is made available as an electronic reprint (preprint) with permission of e-Century Publishing. The paper can be found at the following official URL: http://www.ijbmb.org/1205001A.html.  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Biochemistry
spellingShingle DRNTU::Science::Biological sciences::Biochemistry
Mishra, Manisha
Sze, Siu Kwan
Hu, Jiang-Miao
Feng, Zhi Wei
Heese, Klaus
Ramachandran, Umamaheswari
Sundaramurthi, Husvinee
Manavalan, Arulmani
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
description Tianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions of tianma thus led us to investigate its specific effects on neuronal signalling. Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach. We identified 2178 proteins, out of which 74 were found to be altered upon tianma treatment in differentiated mouse neuronal N2a cells. Based on the observed data obtained, we hypothesize that tianma could promote neuro-regenerative processes by inhibiting stress-related proteins and mobilizing neuroprotective genes such as Nxn, Dbnl, Mobkl3, Clic4, Mki67 and Bax with various regenerative modalities and capacities related to neuro-synaptic plasticity.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Mishra, Manisha
Sze, Siu Kwan
Hu, Jiang-Miao
Feng, Zhi Wei
Heese, Klaus
Ramachandran, Umamaheswari
Sundaramurthi, Husvinee
Manavalan, Arulmani
format Article
author Mishra, Manisha
Sze, Siu Kwan
Hu, Jiang-Miao
Feng, Zhi Wei
Heese, Klaus
Ramachandran, Umamaheswari
Sundaramurthi, Husvinee
Manavalan, Arulmani
author_sort Mishra, Manisha
title Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
title_short Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
title_full Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
title_fullStr Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
title_full_unstemmed Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
title_sort gastrodia elata blume (tianma) mobilizes neuro-protective capacities
publishDate 2014
url https://hdl.handle.net/10356/106235
http://hdl.handle.net/10220/23952
http://www.ijbmb.org/1205001A.html
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