The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

• Main Authors: Ginhoux, Florent, Su, I-hsin, Gunawan, Merry, Venkatesan, Nandini, Loh, Jia Tong, Wong, Jong Fu, Berger, Heidi, Neo, Wen Hao, Li, Liang Yao Jackson, La Win, Myint Khun, Yau, Yin Hoe, Guo, Tiannan, See, Peter Chi Ee, Yamazaki, Sayuri, Chin, Keh Chuang, Gingras, Alexandre R., Shochat, Susana Geifman, Ng, Lai Guan, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/106244; http://hdl.handle.net/10220/34629
• Institution: Nanyang Technological University

A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation has been suggested, but the molecular mechanisms underpinning this extranuclear function have remained unclear. Here we found that Ezh2 regulated the integrin signaling and adhesion dynamics of neutrophils an...