Novel phytochemical antibiotic conjugates as multitarget inhibitors of pseudomononas aeruginosa GyrB/ParE and DHFR

• Main Authors: Jayaraman, Premkumar, Lim, ChuSing, Siddiqi, Mohammad Imran, Sakharkar, Kishore R., Dhillon, Sarinder K., Sakharkar, Meena K.
• Other Authors: BioMedical Engineering Research Centre
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/106310; http://hdl.handle.net/10220/23996
• Institution: Nanyang Technological University

Background: There is a dearth of treatment options for community-acquired and nosocomial Pseudomonas infections due to several rapidly emerging multidrug resistant phenotypes, which show resistance even to combination therapy. As an alternative, developing selective promiscuous hybrid compounds for...