Nanotransducers for near-infrared photoregulation in biomedicine
Photoregulation, which utilizes light to remotely control biological events, provides a precise way to decipher biology and innovate in medicine; however, its potential is limited by the shallow tissue penetration and/or phototoxicity of ultraviolet (UV)/visible light that are required to match the...
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sg-ntu-dr.10356-1063162023-12-29T06:50:24Z Nanotransducers for near-infrared photoregulation in biomedicine Li, Jingchao Duan, Hongwei Pu, Kanyi School of Chemical and Biomedical Engineering Photoregulation Engineering::Chemical engineering Nanotransducers Photoregulation, which utilizes light to remotely control biological events, provides a precise way to decipher biology and innovate in medicine; however, its potential is limited by the shallow tissue penetration and/or phototoxicity of ultraviolet (UV)/visible light that are required to match the optical responses of endogenous photosensitive substances. Thereby, biologically friendly near‐infrared (NIR) light with improved tissue penetration is desired for photoregulation. Since there are a few endogenous biomolecules absorbing or emitting light in the NIR region, the development of molecular transducers is essential to convert NIR light into the cues for regulation of biological events. In this regard, optical nanomaterials able to convert NIR light into UV/visible light, heat, or free radicals are suitable for this task. Here, the recent developments of optical nanotransducers for NIR‐light‐mediated photoregulation in medicine are summarized. The emerging applications, including photoregulation of neural activity, gene expression, and visual systems, as well as photochemical tissue bonding, are highlighted, along with the design principles of nanotransducers. Moreover, the current challenges and perspectives in this field are discussed. MOE (Min. of Education, S’pore) Accepted version 2019-08-19T03:05:03Z 2019-12-06T22:08:58Z 2019-08-19T03:05:03Z 2019-12-06T22:08:58Z 2019 2019 Journal Article Li, J., Duan, H., & Pu, K. (2019). Nanotransducers for near‐infrared photoregulation in biomedicine. Advanced Materials, 1901607-. doi:10.1002/adma.201901607 0935-9648 https://hdl.handle.net/10356/106316 http://hdl.handle.net/10220/49680 10.1002/adma.201901607 213480 en Advanced Materials This is the peer reviewed version of the following article: Li, J., Duan, H., & Pu, K. (2019). Nanotransducers for near‐infrared photoregulation in biomedicine. Advanced Materials, 1901607-. doi10.1002/adma.201901607, which has been published in final form at https://doi.org/10.1002/adma.201901607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. 40 p. application/pdf |
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Photoregulation Engineering::Chemical engineering Nanotransducers Li, Jingchao Duan, Hongwei Pu, Kanyi Nanotransducers for near-infrared photoregulation in biomedicine |
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Photoregulation, which utilizes light to remotely control biological events, provides a precise way to decipher biology and innovate in medicine; however, its potential is limited by the shallow tissue penetration and/or phototoxicity of ultraviolet (UV)/visible light that are required to match the optical responses of endogenous photosensitive substances. Thereby, biologically friendly near‐infrared (NIR) light with improved tissue penetration is desired for photoregulation. Since there are a few endogenous biomolecules absorbing or emitting light in the NIR region, the development of molecular transducers is essential to convert NIR light into the cues for regulation of biological events. In this regard, optical nanomaterials able to convert NIR light into UV/visible light, heat, or free radicals are suitable for this task. Here, the recent developments of optical nanotransducers for NIR‐light‐mediated photoregulation in medicine are summarized. The emerging applications, including photoregulation of neural activity, gene expression, and visual systems, as well as photochemical tissue bonding, are highlighted, along with the design principles of nanotransducers. Moreover, the current challenges and perspectives in this field are discussed. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Li, Jingchao Duan, Hongwei Pu, Kanyi |
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Article |
author |
Li, Jingchao Duan, Hongwei Pu, Kanyi |
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Li, Jingchao |
title |
Nanotransducers for near-infrared photoregulation in biomedicine |
title_short |
Nanotransducers for near-infrared photoregulation in biomedicine |
title_full |
Nanotransducers for near-infrared photoregulation in biomedicine |
title_fullStr |
Nanotransducers for near-infrared photoregulation in biomedicine |
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Nanotransducers for near-infrared photoregulation in biomedicine |
title_sort |
nanotransducers for near-infrared photoregulation in biomedicine |
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2019 |
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https://hdl.handle.net/10356/106316 http://hdl.handle.net/10220/49680 |
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