Zwitterionic polymer design that inhibits aggregation and facilitates insulin refolding : mechanistic insights and importance of hydrophobicity

• Main Authors: Rajan, Robin, Suzuki, Yu, Matsumura, Kazuaki
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Hydrophobicity; Protein Aggregation; DRNTU::Engineering::Chemical engineering
• Online Access: https://hdl.handle.net/10356/106332; http://hdl.handle.net/10220/48901
• Institution: Nanyang Technological University

The synthesis of a zwitterionic polymer, poly‐sulfobetaine (poly‐SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal th...