Maternal separation does not produce a significant behavioral change in mice
Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previousl...
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sg-ntu-dr.10356-1065592023-02-28T16:58:57Z Maternal separation does not produce a significant behavioral change in mice Tan, Shawn Ho, Hin San Song, Anna Yoonsu Low, Joey Je, Shawn Hyunsoo School of Biological Sciences Maternal Separation DRNTU::Science::Biological sciences Early-life Stress Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification. MOE (Min. of Education, S’pore) Published version 2019-06-26T03:06:02Z 2019-12-06T22:14:09Z 2019-06-26T03:06:02Z 2019-12-06T22:14:09Z 2017 Journal Article Tan, S., Ho, H. S., Song, A. Y., Low, J., & Je, S. H. (2017). Maternal separation does not produce a significant behavioral change in mice. Experimental Neurobiology, 26(6), 390-398. doi:10.5607/en.2017.26.6.390 1226-2560 https://hdl.handle.net/10356/106559 http://hdl.handle.net/10220/48939 10.5607/en.2017.26.6.390 en Experimental Neurobiology © 2017 Experimental Neurobiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 9 p. application/pdf |
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Maternal Separation DRNTU::Science::Biological sciences Early-life Stress Tan, Shawn Ho, Hin San Song, Anna Yoonsu Low, Joey Je, Shawn Hyunsoo Maternal separation does not produce a significant behavioral change in mice |
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Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification. |
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School of Biological Sciences |
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School of Biological Sciences Tan, Shawn Ho, Hin San Song, Anna Yoonsu Low, Joey Je, Shawn Hyunsoo |
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Article |
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Tan, Shawn Ho, Hin San Song, Anna Yoonsu Low, Joey Je, Shawn Hyunsoo |
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Tan, Shawn |
title |
Maternal separation does not produce a significant behavioral change in mice |
title_short |
Maternal separation does not produce a significant behavioral change in mice |
title_full |
Maternal separation does not produce a significant behavioral change in mice |
title_fullStr |
Maternal separation does not produce a significant behavioral change in mice |
title_full_unstemmed |
Maternal separation does not produce a significant behavioral change in mice |
title_sort |
maternal separation does not produce a significant behavioral change in mice |
publishDate |
2019 |
url |
https://hdl.handle.net/10356/106559 http://hdl.handle.net/10220/48939 |
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1759858065455185920 |