Maternal separation does not produce a significant behavioral change in mice

Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previousl...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Shawn, Ho, Hin San, Song, Anna Yoonsu, Low, Joey, Je, Shawn Hyunsoo
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/106559
http://hdl.handle.net/10220/48939
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-106559
record_format dspace
spelling sg-ntu-dr.10356-1065592023-02-28T16:58:57Z Maternal separation does not produce a significant behavioral change in mice Tan, Shawn Ho, Hin San Song, Anna Yoonsu Low, Joey Je, Shawn Hyunsoo School of Biological Sciences Maternal Separation DRNTU::Science::Biological sciences Early-life Stress Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification. MOE (Min. of Education, S’pore) Published version 2019-06-26T03:06:02Z 2019-12-06T22:14:09Z 2019-06-26T03:06:02Z 2019-12-06T22:14:09Z 2017 Journal Article Tan, S., Ho, H. S., Song, A. Y., Low, J., & Je, S. H. (2017). Maternal separation does not produce a significant behavioral change in mice. Experimental Neurobiology, 26(6), 390-398. doi:10.5607/en.2017.26.6.390 1226-2560 https://hdl.handle.net/10356/106559 http://hdl.handle.net/10220/48939 10.5607/en.2017.26.6.390 en Experimental Neurobiology © 2017 Experimental Neurobiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 9 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Maternal Separation
DRNTU::Science::Biological sciences
Early-life Stress
spellingShingle Maternal Separation
DRNTU::Science::Biological sciences
Early-life Stress
Tan, Shawn
Ho, Hin San
Song, Anna Yoonsu
Low, Joey
Je, Shawn Hyunsoo
Maternal separation does not produce a significant behavioral change in mice
description Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Tan, Shawn
Ho, Hin San
Song, Anna Yoonsu
Low, Joey
Je, Shawn Hyunsoo
format Article
author Tan, Shawn
Ho, Hin San
Song, Anna Yoonsu
Low, Joey
Je, Shawn Hyunsoo
author_sort Tan, Shawn
title Maternal separation does not produce a significant behavioral change in mice
title_short Maternal separation does not produce a significant behavioral change in mice
title_full Maternal separation does not produce a significant behavioral change in mice
title_fullStr Maternal separation does not produce a significant behavioral change in mice
title_full_unstemmed Maternal separation does not produce a significant behavioral change in mice
title_sort maternal separation does not produce a significant behavioral change in mice
publishDate 2019
url https://hdl.handle.net/10356/106559
http://hdl.handle.net/10220/48939
_version_ 1759858065455185920