A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug

• Main Authors: Zhao, Yang, Luo, Zhong, Li, Menghuan, Qu, Qiuyu, Ma, Xing, Yu, Shu-Hong, Zhao, Yanli
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Engineering::Materials::Nanostructured materials
• Online Access: https://hdl.handle.net/10356/106582; http://hdl.handle.net/10220/25002
• Institution: Nanyang Technological University

Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH-responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica...