Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We s...

Full description

Saved in:
Bibliographic Details
Main Authors: Ng, Calista Keow Leng, Herath, Wishva, Lili, Sun, Hutchins, Andrew P, Robson, Paul, Kolatkar, Prasanna R, Stanton, Lawrence W, Aksoy, Irene, Jauch, Ralf, Chen, Jiaxuan, Dyla, Mateusz, Divakar, Ushashree, Bogu, Gireesh K, Teo, Roy
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/106625
http://hdl.handle.net/10220/25036
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English