Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates

An efficient glycosylation method to synthesize 2-deoxy-C-aryl glycosides was developed. This C-glycosylation strategy is based on a palladium-catalyzed desulfitative Ferrier-type coupling reaction of glycals and sodium arylsulfinates. A series of C-aryl glycosides were obtained in moderate to good...

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Main Authors: Ma, Jimei, Xiang, Shaohua, Jiang, Hong, Liu, Xue-Wei
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
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Online Access:https://hdl.handle.net/10356/106693
http://hdl.handle.net/10220/25083
http://dx.doi.org/10.1002/ejoc.201403550
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1066932019-12-06T22:16:25Z Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates Ma, Jimei Xiang, Shaohua Jiang, Hong Liu, Xue-Wei School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry An efficient glycosylation method to synthesize 2-deoxy-C-aryl glycosides was developed. This C-glycosylation strategy is based on a palladium-catalyzed desulfitative Ferrier-type coupling reaction of glycals and sodium arylsulfinates. A series of C-aryl glycosides were obtained in moderate to good yields with exclusive regio- and stereoselectivities. The anomeric selectivity was found to depend on the configuration of the C3 substituent of the glycals. 2015-02-24T07:01:40Z 2019-12-06T22:16:25Z 2015-02-24T07:01:40Z 2019-12-06T22:16:25Z 2015 2015 Journal Article Ma, J., Xiang, S., Jiang, H., & Liu, X.-W. (2015). Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates. European journal of organic chemistry, 2015(5), 949-952. 1434-193X https://hdl.handle.net/10356/106693 http://hdl.handle.net/10220/25083 http://dx.doi.org/10.1002/ejoc.201403550 en European journal of organic chemistry © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry
spellingShingle DRNTU::Science::Chemistry::Organic chemistry
Ma, Jimei
Xiang, Shaohua
Jiang, Hong
Liu, Xue-Wei
Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
description An efficient glycosylation method to synthesize 2-deoxy-C-aryl glycosides was developed. This C-glycosylation strategy is based on a palladium-catalyzed desulfitative Ferrier-type coupling reaction of glycals and sodium arylsulfinates. A series of C-aryl glycosides were obtained in moderate to good yields with exclusive regio- and stereoselectivities. The anomeric selectivity was found to depend on the configuration of the C3 substituent of the glycals.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Ma, Jimei
Xiang, Shaohua
Jiang, Hong
Liu, Xue-Wei
format Article
author Ma, Jimei
Xiang, Shaohua
Jiang, Hong
Liu, Xue-Wei
author_sort Ma, Jimei
title Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
title_short Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
title_full Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
title_fullStr Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
title_full_unstemmed Palladium-catalyzed stereoselective C-glycosylation of glycals with sodium arylsulfinates
title_sort palladium-catalyzed stereoselective c-glycosylation of glycals with sodium arylsulfinates
publishDate 2015
url https://hdl.handle.net/10356/106693
http://hdl.handle.net/10220/25083
http://dx.doi.org/10.1002/ejoc.201403550
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