Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

• Main Authors: Hestermann, Dietmar, Temel, Yasin, Blokland, Arjan, Lim, Lee Wei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: https://hdl.handle.net/10356/106718; http://hdl.handle.net/10220/25117
• Institution: Nanyang Technological University

Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-H...