Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia

• Main Authors: Gallart-Palau, Xavier, Serra, Aida, Qian, Jingru, Chen, Christopher P., Kalaria, Raj N., Sze, Siu Kwan
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• 在線閱讀: https://hdl.handle.net/10356/106751; http://hdl.handle.net/10220/25092

Progressive synaptic failure precedes the loss of neurons and decline in cognitive function in neurodegenerative disorders, but the specific proteins and posttranslational modifications that promote synaptic failure in vascular dementia (VaD) remain largely unknown. We therefore used an isobaric tag...