Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia

• Main Authors: Gallart-Palau, Xavier, Serra, Aida, Qian, Jingru, Chen, Christopher P., Kalaria, Raj N., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: https://hdl.handle.net/10356/106751; http://hdl.handle.net/10220/25092
• Institution: Nanyang Technological University

Progressive synaptic failure precedes the loss of neurons and decline in cognitive function in neurodegenerative disorders, but the specific proteins and posttranslational modifications that promote synaptic failure in vascular dementia (VaD) remain largely unknown. We therefore used an isobaric tag...