Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia

• المؤلفون الرئيسيون: Gallart-Palau, Xavier, Serra, Aida, Qian, Jingru, Chen, Christopher P., Kalaria, Raj N., Sze, Siu Kwan
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106751; http://hdl.handle.net/10220/25092

Progressive synaptic failure precedes the loss of neurons and decline in cognitive function in neurodegenerative disorders, but the specific proteins and posttranslational modifications that promote synaptic failure in vascular dementia (VaD) remain largely unknown. We therefore used an isobaric tag...