Molecular dynamics simulations demonstrate the regulation of DNA-DNA attraction by H4 histone tail acetylations and mutations

• Main Authors: Korolev, Nikolay, Yu, Hang, Lyubartsev, Alexander P., Nordenskiöld, Lars
• Other Authors: Case, David A.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106867; http://hdl.handle.net/10220/25198; http://dx.doi.org/10.1002/bip.22499
• Institution: Nanyang Technological University

The positively charged N-terminal histone tails play a crucial role in chromatin compaction and are important modulators of DNA transcription, recombination, and repair. The detailed mechanism of the interaction of histone tails with DNA remains elusive. To model the unspecific interaction of histon...