Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach

• Main Authors: Su, Ying, Pan, Sijun, Li, Zhengqiu, Li, Lin, Wu, Xiaoyuan, Hao, Piliang, Sze, Siu Kwan, Yao, Shao Q.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106925; http://hdl.handle.net/10220/25151
• Institution: Nanyang Technological University

MLN8237 is a highly potent and presumably selective inhibitor of Aurora kinase A (AKA) and has shown promising antitumor activities. Like other kinase inhibitors which target the ATP-binding site of kinases, MLN8237 might be expected to have potential cellular off-targets. Herein, we report the firs...