Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach

• المؤلفون الرئيسيون: Su, Ying, Pan, Sijun, Li, Zhengqiu, Li, Lin, Wu, Xiaoyuan, Hao, Piliang, Sze, Siu Kwan, Yao, Shao Q.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106925; http://hdl.handle.net/10220/25151
• المؤسسة: Nanyang Technological University

MLN8237 is a highly potent and presumably selective inhibitor of Aurora kinase A (AKA) and has shown promising antitumor activities. Like other kinase inhibitors which target the ATP-binding site of kinases, MLN8237 might be expected to have potential cellular off-targets. Herein, we report the firs...