Structure of a left-handed DNA G-quadruplex

Structure of a left-handed DNA G-quadruplex

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphi...

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Bibliographic Details
Main Authors: Chung, Wan Jun, Heddi, Brahim, Schmitt, Emmanuelle, Lim, Kah Wai, Mechulam, Yves, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
Subjects:
G-quadruplex
left-handed helix
nucleic acid
NMR
X-ray crystallography
Online Access:https://hdl.handle.net/10356/107059
http://hdl.handle.net/10220/25356
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Institution: Nanyang Technological University
Language: English
Description
Summary:Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

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