N-heterocyclic carbene organocatalytic reductive β,β-coupling reactions of nitroalkenes via radical intermediates

• Main Authors: Du, Yu, Wang, Yuhuang, Li, Xin, Shao, Yaling, Li, Guohui, Webster, Richard D., Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/107178; http://hdl.handle.net/10220/25333; http://dx.doi.org/10.1021/ol5027415
• Institution: Nanyang Technological University

An unprecedented N-heterocyclic carbene catalytic reductive β,β-carbon coupling of α,β-nitroalkenes, by using an organic substrate to mimic the one-electron oxidation role of the pyruvate ferredoxin oxidoreductase (PFOR) in living systems, has been developed. The reaction goes through a radical anio...