A unique Oct4 interface is crucial for reprogramming to pluripotency

• Main Authors: Esch, Daniel, Pogenberg, Vivian, Cojocaru, Vlad, vom Bruch, Hermann, Vahokoski, Juha, Groves, Matthew R., Han, Dong, Drexler, Hannes C. A., Araúzo-Bravo, Marcos J., Ng, Calista K. L., Jauch, Ralf, Wilmanns, Matthias, Schöler, Hans R.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: https://hdl.handle.net/10356/107335; http://hdl.handle.net/10220/18028; http://dx.doi.org/10.1038/ncb2680
• Institution: Nanyang Technological University

Terminally differentiated cells can be reprogrammed to pluripotency by the forced expression of Oct4, Sox2, Klf4 and c-Myc1, 2. However, it remains unknown how this leads to the multitude of epigenetic changes observed during the reprogramming process. Interestingly, Oct4 is the only factor that can...