Dual role of the anaphase promoting complex/cyclosome in regulating stemness and differentiation in human primary keratinocytes

• Main Authors: Quek, Ling Shih, Grasset, Nicolas, Robinson, Kim S., Bellanger, Sophie, Jasmen, Joanita
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Cyclosome; Keratinocytes; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/107471; http://hdl.handle.net/10220/49713
• Institution: Nanyang Technological University

Cdc20 and Cdh1 activate the anaphase-promoting complex/cyclosome, a master cell cycle regulator. Although cell cycle modifications occur during differentiation of stem cells, a role for the anaphase-promoting complex/cyclosome on stem cell fate has not been established in embryonic or adult human ti...