Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment

Hooks et al. posit that gastrointestinal microbes alter the end state of development indirectly. Here, we present the immune system as the link that facilitates communication between the gut and the brain. Illustrating the case of autism spectrum disorder, we explicate the role of the immune system...

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Main Authors:	Azhari, Atiqah, Azizan, Farouq, Esposito, Gianluca
Other Authors:	School of Social Sciences
Format:	Article
Language:	English
Published:	2019
Subjects:	Gut Microbiota Neurodevelopment Social sciences::Psychology
Online Access:	https://hdl.handle.net/10356/107503 http://hdl.handle.net/10220/49688 http://dx.doi.org/10.1017/S0140525X18002790
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-107503
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spelling	sg-ntu-dr.10356-1075032019-12-10T13:21:43Z Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment Azhari, Atiqah Azizan, Farouq Esposito, Gianluca School of Social Sciences Social and Affiliative Neuroscience Lab Gut Microbiota Neurodevelopment Social sciences::Psychology Hooks et al. posit that gastrointestinal microbes alter the end state of development indirectly. Here, we present the immune system as the link that facilitates communication between the gut and the brain. Illustrating the case of autism spectrum disorder, we explicate the role of the immune system in responding to microbial dysbiosis by inducing an inflammatory state that affects neurodevelopment. We propose two models: directly, within the infant, and indirectly, via maternal and infant systems. Accepted version 2019-08-20T03:29:46Z 2019-12-06T22:32:39Z 2019-08-20T03:29:46Z 2019-12-06T22:32:39Z 2019 Journal Article Azhari, A., Azizan, F., & Esposito, G. (2019). Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment. Behavioral and Brain Sciences, 42, e64-. doi:10.1017/S0140525X18002790 0140-525X https://hdl.handle.net/10356/107503 http://hdl.handle.net/10220/49688 http://dx.doi.org/10.1017/S0140525X18002790 en Behavioral and Brain Sciences © 2019 Cambridge University Press. All rights reserved. This paper was published in Behavioral and Brain Sciences and is made available with permission of Cambridge University Press. 5 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	Gut Microbiota Neurodevelopment Social sciences::Psychology
spellingShingle	Gut Microbiota Neurodevelopment Social sciences::Psychology Azhari, Atiqah Azizan, Farouq Esposito, Gianluca Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
description	Hooks et al. posit that gastrointestinal microbes alter the end state of development indirectly. Here, we present the immune system as the link that facilitates communication between the gut and the brain. Illustrating the case of autism spectrum disorder, we explicate the role of the immune system in responding to microbial dysbiosis by inducing an inflammatory state that affects neurodevelopment. We propose two models: directly, within the infant, and indirectly, via maternal and infant systems.
author2	School of Social Sciences
author_facet	School of Social Sciences Azhari, Atiqah Azizan, Farouq Esposito, Gianluca
format	Article
author	Azhari, Atiqah Azizan, Farouq Esposito, Gianluca
author_sort	Azhari, Atiqah
title	Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
title_short	Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
title_full	Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
title_fullStr	Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
title_full_unstemmed	Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
title_sort	beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
publishDate	2019
url	https://hdl.handle.net/10356/107503 http://hdl.handle.net/10220/49688 http://dx.doi.org/10.1017/S0140525X18002790
_version_	1681049214295998464

Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment

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