Postsynaptic mechanisms render syn I/II/III mice highly responsive to psychostimulants

• Main Authors: Pogorelov, Vladimir M., Kao, Hung-Teh, Augustine, George James, Wetsel, William C.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Psychostimulants; Science::Medicine; Behavior
• Online Access: https://hdl.handle.net/10356/107506; http://hdl.handle.net/10220/49720
• Institution: Nanyang Technological University

Background:Synapsins are encoded by SYN I, SYN II, and SYN III, and they regulate neurotransmitter release by maintaining a reserve pool of synaptic vesicles. Methods:Presynaptic dopamine responses to cocaine were examined by microdialysis, and postsynaptic responses were evaluated to various dopami...