A renal-clearable duplex optical reporter for real-time imaging of contrast-induced acute kidney injury

• Main Authors: Huang, Jiaguo, Lyu, Yan, Li, Jingchao, Cheng, Penghui, Jiang, Yuyan, Pu, Kanyi
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Renal-Clearable Duplex Optical Reporter; Acute Kidney Injury
• Online Access: https://hdl.handle.net/10356/136719
• Institution: Nanyang Technological University

Despite its high morbidity and mortality, contrast‐induced acute kidney injury (CIAKI) remains a diagnostic dilemma because it relies on in vitro detection of insensitive late‐stage blood and urinary biomarkers. We report the synthesis of an activatable duplex reporter (ADR) for real‐time in vivo im...