Carbene-catalyzed asymmetric modification of carboxylic acids and sulfonamides

• Main Author: Liu, Yingguo
• Other Authors: Chi Robin Yonggui
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Chemistry::Organic chemistry::Organic synthesis; Science::Chemistry::Organic chemistry::Antibiotics; Science::Medicine::Pharmacy::Pharmaceutical technology
• Online Access: https://hdl.handle.net/10356/136869
• Institution: Nanyang Technological University

In this thesis, we demonstrated the new reaction mode enabled by NHC in the enantioselective synthesis of 3-substituted phthalides, which could be used for structural modification on heteroatoms within the medicinally significant molecules. Our method shall expand the synth...