Carbene-catalyzed asymmetric modification of carboxylic acids and sulfonamides

• 主要作者: Liu, Yingguo
• 其他作者: Chi Robin Yonggui
• 格式: Thesis-Doctor of Philosophy
• 語言: English
• 出版: Nanyang Technological University 2020
• 主題: Science::Chemistry::Organic chemistry::Organic synthesis; Science::Chemistry::Organic chemistry::Antibiotics; Science::Medicine::Pharmacy::Pharmaceutical technology
• 在線閱讀: https://hdl.handle.net/10356/136869

In this thesis, we demonstrated the new reaction mode enabled by NHC in the enantioselective synthesis of 3-substituted phthalides, which could be used for structural modification on heteroatoms within the medicinally significant molecules. Our method shall expand the synth...