(Guanidine) copper complex-catalyzed enantioselective dynamic kinetic allylic alkynylation under biphasic condition

• Main Authors: Cui, Xi-Yang, Ge, Yicen, Tan, Siu Min, Jiang, Huan, Tan, Davin, Lu, Yunpeng, Lee, Richmond, Tan, Choon-Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Guanidine; Anions
• Online Access: https://hdl.handle.net/10356/137033
• Institution: Nanyang Technological University

Highly enantioselective allylic alkynylation of racemic bromides under biphasic condition is furnished in this report. This approach employs functionalized terminal alkynes as pro-nucleophiles and provides 6- and 7-membered cyclic 1,4-enynes with high yields and excellent enantioselectivities (up to...