A novel polymer drug conjugate for the sustained release of ganciclovir

• Main Author: Dickescheid, Andreas
• Other Authors: Subbu S. Venkatraman
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Engineering::Materials::Biomaterials
• Online Access: https://hdl.handle.net/10356/137127
• Institution: Nanyang Technological University

Ocular manifestation of cytomegalovirus (CMV retinitis) remains the most common AIDS-related ocular complication which occurs in 40% of HIV patients and causes loss of vision or blindness [1]. Intravitreal injection of ganciclovir (an inhibitor of the viral DNA polymerase [2]) is the current gold st...