Reflection-based thin-core modal interferometry optical fiber functionalized with PAA-PBA/PVA for glucose detection under physiological pH
A phenylboronic-acid-derivatized poly (acrylic acid) (PAA-PBA)/poly(vinyl alcohol) (PVA) functionalized thin-core fiber (TCF) optical sensor is proposed for glucose detection. The unique Michelson-type fiber interferometer sensor was fabricated by splicing a short segment of TCF with a single-mode f...
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المؤلفون الرئيسيون: | , , , , , , , |
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مؤلفون آخرون: | |
التنسيق: | مقال |
اللغة: | English |
منشور في: |
2020
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الموضوعات: | |
الوصول للمادة أونلاين: | https://hdl.handle.net/10356/137184 |
الوسوم: |
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المؤسسة: | Nanyang Technological University |
اللغة: | English |
الملخص: | A phenylboronic-acid-derivatized poly (acrylic acid) (PAA-PBA)/poly(vinyl alcohol) (PVA) functionalized thin-core fiber (TCF) optical sensor is proposed for glucose detection. The unique Michelson-type fiber interferometer sensor was fabricated by splicing a short segment of TCF with a single-mode fiber, where the tip of TCF was melted into a rounded shape. PAA-PBA was synthesized by grafting PBA onto the PAA chain using N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as coupling reagent. Multilayer films of PAA-PBA and PVA were subsequently functionalized onto the fiber-optic Michelson interferometer structure through layer-by-layer assembly. Experiments showed that the PAA-PBA/PVA functionalized fiber-optic probe exhibits glucose-sensitive behavior under physiological pH. The proposed sensor offers benefits such as simple fabrication, compact size, and glucose selectivity and has potential applications, such as insulin release system, in a biodevice. |
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