Carbene-catalyzed α-carbon amination of chloroaldehydes for enantioselective access to dihydroquinoxaline derivatives

• Main Authors: Huang, Ruoyan, Chen, Xingkuan, Mou, Chengli, Luo, Guoyong, Li, Yongjia, Li, Xiangyang, Xue, Wei, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Enantioselectivity; N-Heterocyclic Carbene Catalysis
• Online Access: https://hdl.handle.net/10356/137763
• Institution: Nanyang Technological University

An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.