Carbene-catalyzed α-carbon amination of chloroaldehydes for enantioselective access to dihydroquinoxaline derivatives

Carbene-catalyzed α-carbon amination of chloroaldehydes for enantioselective access to dihydroquinoxaline derivatives

An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

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書目詳細資料
Main Authors: Huang, Ruoyan, Chen, Xingkuan, Mou, Chengli, Luo, Guoyong, Li, Yongjia, Li, Xiangyang, Xue, Wei, Jin, Zhichao, Chi, Robin Yonggui
其他作者: School of Physical and Mathematical Sciences
格式: Article
語言:English
出版: 2020
主題:
Science::Chemistry::Organic chemistry
Enantioselectivity
N-Heterocyclic Carbene Catalysis
在線閱讀:https://hdl.handle.net/10356/137763
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機構: Nanyang Technological University
語言: English

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https://hdl.handle.net/10356/137763

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