NaOH-promoted chemoselective cascade cyclization of cyclopropyl esters with unsaturated imines : access to bioactive cyclopenta[c]pyridine derivatives

• Main Authors: Pan, Dingwu, Mou, Chengli, Zan, Ningning, Lv, Ya, Song, Bao-An, Chi, Robin Yonggui, Jin, Zhichao
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; Cycloaddition; Chemoselective
• Online Access: https://hdl.handle.net/10356/137826
• Institution: Nanyang Technological University

A chemoselective cascade cycloaddition reaction is developed for green and efficient access to cyclopenta[c]pyridine derivatives. Simple and inexpensive NaOH is used as the sole catalyst for this process. The δ-carbon of cyclopropyl ester is activated as a nucleophilic carbon to initiate highly chem...