Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates

By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification.

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Main Authors:	Tan, Xiaohong, Yang, Renliang, Liu, Chuan-Fa
Other Authors:	School of Biological Sciences
Format:	Article
Language:	English
Published:	2020
Subjects:	Science::Biological sciences Peptide Thioester Ligation
Online Access:	https://hdl.handle.net/10356/138242
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-1382422020-04-29T08:18:57Z Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa School of Biological Sciences Science::Biological sciences Peptide Thioester Ligation By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification. MOE (Min. of Education, S’pore) 2020-04-29T08:18:57Z 2020-04-29T08:18:57Z 2018 Journal Article Tan, X., Yang, R., & Liu, C.-F. (2018). Facilitating subtiligase-catalyzed peptide ligation reactions by using peptide thioester substrates. Organic Letters, 20(21), 6691-6694. doi:10.1021/acs.orglett.8b02747 1523-7060 https://hdl.handle.net/10356/138242 10.1021/acs.orglett.8b02747 30350676 2-s2.0-85055124833 21 20 6691 6694 en Organic Letters © 2018 American Chemical Society. All rights reserved.
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	Science::Biological sciences Peptide Thioester Ligation
spellingShingle	Science::Biological sciences Peptide Thioester Ligation Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
description	By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa
format	Article
author	Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa
author_sort	Tan, Xiaohong
title	Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
title_short	Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
title_full	Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
title_fullStr	Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
title_full_unstemmed	Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
title_sort	facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
publishDate	2020
url	https://hdl.handle.net/10356/138242
_version_	1681057976779014144

Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates

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