Carbene-catalyzed enal γ-carbon addition to α-ketophosphonates for enantioselective access to bioactive 2-pyranylphosphonates

• المؤلفون الرئيسيون: Sun, Jun, He, Fangcheng, Wang, Zhongyao, Pan, Dingwu, Zheng, Pengcheng, Mou, Chengli, Jin, Zhichao, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Chemistry::Organic chemistry; NHC Catalyst; Enantioselectivities
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/138269

A carbene-catalyzed enantioselective [4+2] cycloaddition reaction between a,b-unsaturated aldehydes and a-ketophosphonates is developed. The reaction affords chiral 2-pyranylphosphonates with excellent enantioselectivities. The optically enriched phosphonate products bear multiple functional groups,...