Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples

This work reports an interferometric optical microfiber sensor functionalized with nitrogen- and sulfur-codoped carbon dots (CDs) for the detection of ferric ions (Fe3+). Compared to other CD-based ferric ion sensors, the sensing mechanism of this presented sensor is dependent on the refractive inde...

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Main Authors: Yap, Stephanie Hui Kit, Chan, Kok Ken, Zhang, Gong, Tjin, Swee Chuan, Yong, Ken-Tye
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/138312
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1383122020-05-02T06:27:04Z Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples Yap, Stephanie Hui Kit Chan, Kok Ken Zhang, Gong Tjin, Swee Chuan Yong, Ken-Tye School of Electrical and Electronic Engineering Engineering::Electrical and electronic engineering Carbon Dots Heavy Metal Ion This work reports an interferometric optical microfiber sensor functionalized with nitrogen- and sulfur-codoped carbon dots (CDs) for the detection of ferric ions (Fe3+). Compared to other CD-based ferric ion sensors, the sensing mechanism of this presented sensor is dependent on the refractive index modulations due to selective Fe3+ adsorption onto the CD binding sites at the tapered region. This is the first study in which CD-based sensing was performed at the solid phase as a chelator, which does not rely on its fluorescence properties. The detection performance of the proposed sensor is not only comparable to a conventional fluorescence-based CD nanoprobe sensor but also capable of delivering quantitative analysis results and ease of translation to a sensor device for on-site detection. The presented sensor exhibits Fe3+ detection sensitivity of 0.0061 nm/(μg/L) in the linear detection range between 0 and 300 μg/L and a detection limit of 0.77 μg/L based on the Langmuir isotherm model. Finally, the potential use of the CD-functionalized optical microfiber sensor in the real environmental and biological Fe3+ monitoring applications has also been validated in this work. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-05-02T06:27:04Z 2020-05-02T06:27:04Z 2019 Journal Article Yap, S. H. K., Chan, K. K., Zhang, G., Tjin, S. C., & Yong, K.-T. (2019). Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples. ACS Applied Materials & Interfaces, 11(31), 28546-28553. doi:10.1021/acsami.9b08934 1944-8252 https://hdl.handle.net/10356/138312 10.1021/acsami.9b08934 31 11 28546 28553 en ACS Applied Materials & Interfaces This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.9b08934 application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Engineering::Electrical and electronic engineering
Carbon Dots
Heavy Metal Ion
spellingShingle Engineering::Electrical and electronic engineering
Carbon Dots
Heavy Metal Ion
Yap, Stephanie Hui Kit
Chan, Kok Ken
Zhang, Gong
Tjin, Swee Chuan
Yong, Ken-Tye
Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
description This work reports an interferometric optical microfiber sensor functionalized with nitrogen- and sulfur-codoped carbon dots (CDs) for the detection of ferric ions (Fe3+). Compared to other CD-based ferric ion sensors, the sensing mechanism of this presented sensor is dependent on the refractive index modulations due to selective Fe3+ adsorption onto the CD binding sites at the tapered region. This is the first study in which CD-based sensing was performed at the solid phase as a chelator, which does not rely on its fluorescence properties. The detection performance of the proposed sensor is not only comparable to a conventional fluorescence-based CD nanoprobe sensor but also capable of delivering quantitative analysis results and ease of translation to a sensor device for on-site detection. The presented sensor exhibits Fe3+ detection sensitivity of 0.0061 nm/(μg/L) in the linear detection range between 0 and 300 μg/L and a detection limit of 0.77 μg/L based on the Langmuir isotherm model. Finally, the potential use of the CD-functionalized optical microfiber sensor in the real environmental and biological Fe3+ monitoring applications has also been validated in this work.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Yap, Stephanie Hui Kit
Chan, Kok Ken
Zhang, Gong
Tjin, Swee Chuan
Yong, Ken-Tye
format Article
author Yap, Stephanie Hui Kit
Chan, Kok Ken
Zhang, Gong
Tjin, Swee Chuan
Yong, Ken-Tye
author_sort Yap, Stephanie Hui Kit
title Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
title_short Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
title_full Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
title_fullStr Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
title_full_unstemmed Carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
title_sort carbon dot-functionalized interferometric optical fiber sensor for detection of ferric ions in biological samples
publishDate 2020
url https://hdl.handle.net/10356/138312
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