TBAJ-876 retains bedaquiline’s activity against subunits c and ε of mycobacterium tuberculosis F-ATP synthase

• Main Authors: Sarathy, Jickky Palmae, Ragunathan, Priya, Shin, Joon, Cooper, Christopher B., Upton, Anna M., Grüber, Gerhard, Dick, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Molecular biology; Science::Biological sciences::Biochemistry; ε Subunit; F-ATP Synthase
• Online Access: https://hdl.handle.net/10356/138452
• Institution: Nanyang Technological University

The antituberculosis drug bedaquiline (BDQ) inhibits Mycobacterium tuberculosis F-ATP synthase by interfering with two subunits. Drug binding to the c subunit stalls the rotation of the c ring, while binding to the ε subunit blocks coupling of c ring rotation to ATP synthesis at the catalytic α3:β3...