Drug-free microneedles in the treatment of keloids : a single-blinded intraindividual controlled clinical trial

• Main Authors: Tan, Collin W X, Yeo, David Chen Long, Cao, Taige, Tan, Wei Ding V, Srivastava, Ruchir, Yow, Ai Ping, Tan, Wee Ping, Wong, Damon Wing Kee, Xu, Chenjie, Tey, Hong Liang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Keloid; Needle
• Online Access: https://hdl.handle.net/10356/138551
• Institution: Nanyang Technological University

Keloids are a common skin disorder with significant morbidity. Itch and pain are common symptoms that affect up to 80% of patients. First-line treatment is repeated intralesional corticosteroid injections, which are painful and prone to recurrence of lesions. In a previous study, we observed that solid microneedles exhibited contact-dependent inhibition on cultured keloid and normal skin fibroblasts, in the absence of drugs.