Synthetic biohybrid peptidoglycan oligomers enable pan-bacteria-specific labeling and imaging : in vitro and in vivo

• Main Authors: He Jing-Xi, Hoang, Kim Le Mai, Kho, Shu Hui, Guo, Zhong, Zhong, Wenbin, Thappeta, Kishore Reddy Venkata, Zamudio-Vázquez, Rubi, Hoo, Sin Ni, Xiong, Qirong, Duan, Hongwei, Yang, Liang, Chan-Park, Mary Bee Eng, Liu, Xue-Wei
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry
• Online Access: https://hdl.handle.net/10356/138576
• Institution: Nanyang Technological University

Peptidoglycan is the core component of the bacterial cell wall, which makes it an attractive target for the development of bacterial targeting agents. Intercepting its enzymatic assembly with synthetic substrates allows for labeling and engineering of live bacterial cells. Over the past two decades,...