Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions
An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantag...
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| اللغة: | English |
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2020
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| الوصول للمادة أونلاين: | https://hdl.handle.net/10356/138673 |
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sg-ntu-dr.10356-1386732020-05-11T09:10:01Z Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions Liu, Yanan Xie, Peizhong Sun, Zuolian Wo, Xiangyang Gao, Cuiqing Fu, Weishan Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Sulfones Alcohols An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantage of the synergetic actions of multiple hydrogen bonds rather than relying on an external catalyst and/or additives to achieve high product distribution. 2020-05-11T09:10:01Z 2020-05-11T09:10:01Z 2018 Journal Article Liu, Y., Xie, P., Sun, Z., Wo, X., Gao, C., Fu, W., & Loh, T.-P. (2018). Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions. Organic Letters, 20(17), 5353-5356. doi:10.1021/acs.orglett.8b02188 1523-7060 https://hdl.handle.net/10356/138673 10.1021/acs.orglett.8b02188 30106300 2-s2.0-85053009214 17 20 5353 5356 en Organic Letters © 2018 American Chemical Society. All rights reserved. |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| country |
Singapore |
| collection |
DR-NTU |
| language |
English |
| topic |
Science::Chemistry Sulfones Alcohols |
| spellingShingle |
Science::Chemistry Sulfones Alcohols Liu, Yanan Xie, Peizhong Sun, Zuolian Wo, Xiangyang Gao, Cuiqing Fu, Weishan Loh, Teck-Peng Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| description |
An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantage of the synergetic actions of multiple hydrogen bonds rather than relying on an external catalyst and/or additives to achieve high product distribution. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Liu, Yanan Xie, Peizhong Sun, Zuolian Wo, Xiangyang Gao, Cuiqing Fu, Weishan Loh, Teck-Peng |
| format |
Article |
| author |
Liu, Yanan Xie, Peizhong Sun, Zuolian Wo, Xiangyang Gao, Cuiqing Fu, Weishan Loh, Teck-Peng |
| author_sort |
Liu, Yanan |
| title |
Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| title_short |
Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| title_full |
Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| title_fullStr |
Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| title_full_unstemmed |
Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| title_sort |
direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions |
| publishDate |
2020 |
| url |
https://hdl.handle.net/10356/138673 |
| _version_ |
1681057977163841536 |