Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum

• Main Authors: Rowan, Matthew J. M., Bonnan, Audrey, Zhang, Ke, Amat, Samantha B., Kikuchi, Chikako, Taniguchi, Hiroki, Augustine, George James, Christie, Jason M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Cerebellum; Climbing Fibers
• Online Access: https://hdl.handle.net/10356/138808
• Institution: Nanyang Technological University

Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic a...