Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

• المؤلفون الرئيسيون: Low, Zhen Jie, Xiong, Juan, Xie, Ying, Ma, Guang-Lei, Saw, Howard, Tran, Hoa Thi, Wong, Soo Lin, Pang, Li Mei, Fong, July, Lu, Peng, Hu, Jin-Feng, Liang, Yang, Miao, Yansong, Liang, Zhao-Xun
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences::Biochemistry; Science::Biological sciences::Microbiology; Natural Product; Anti-fungal Agent
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/138959

Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the ag...