Dynamics changes of CRISPR-Cas9 systems induced by high fidelity mutations

• المؤلفون الرئيسيون: Zheng, Liangzhen, Shi, Jiahai, Mu, Yuguang
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Physics; Mutations; Cas9
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/139057

CRISPR-Cas9, a powerful genome editing tool, has widely been applied in biological fields. Since the discovery of CRISPR-Cas9 as an adaptive immune system, it has been gradually modified to perform precise genome editing in eukaryotic cells by creating double-strand breaks. Although it is robust and...