Chromium(III)-catalyzed addition of water and alcohol to α,β-unsaturated ketones for the synthesis of β-hydroxyl and β-alkoxyl ketones in aqueous media

• Main Authors: Yun, Jin-Jin, Liu, Xuan-Yu, Deng, Wei, Chu, Xue-Qiang, Shen, Zhi-Liang, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Alcohols; Ketones
• Online Access: https://hdl.handle.net/10356/139182
• Institution: Nanyang Technological University

An efficient chromium(III) chloride-catalyzed Michael-type reaction of water or alcohol with α,β-unsaturated ketones is developed. A variety of α,β-unsaturated ketones effectively reacted with either water or alcohols to give the corresponding β-hydroxyl ketones or β-alkoxyl ketones in modest to hig...