Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock
Recently, molecular keypad locks have received increasing attention. As a new subgroup of smart biosensors, they show great potential for protecting information as a molecular security data processor, rather than merely molecular recognition and quantitation. Herein, label-free electrochemically tra...
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sg-ntu-dr.10356-1392762020-05-18T07:58:31Z Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock Du, Yan Han, Xu Wang, Chenxu Li, Yunhui Li, Bingling Duan, Hongwei School of Chemical and Biomedical Engineering Engineering::Chemical engineering Keypad Lock Resettable Recently, molecular keypad locks have received increasing attention. As a new subgroup of smart biosensors, they show great potential for protecting information as a molecular security data processor, rather than merely molecular recognition and quantitation. Herein, label-free electrochemically transduced Ag+ and cysteine (Cys) sensors were developed. A molecular keypad lock model with reset function was successfully realized based on the balanced interaction of metal ion with its nucleic acid and chemical ligands. The correct input of “1-2-3” (i.e., “Ag+-Cys-cDNA”) is the only password of such molecular keypad lock. Moreover, the resetting process of either correct or wrong input order could be easily made by Cys, buffer, and DI water treatment. Therefore, our system provides an even smarter system of molecular keypad lock, which could inhibit illegal access of unauthorized users, holding great promise in information protection at the molecular level. MOE (Min. of Education, S’pore) 2020-05-18T07:58:31Z 2020-05-18T07:58:31Z 2017 Journal Article Du, Y., Han, X., Wang, C., Li, Y., Li, B., & Duan, H. (2018). Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock. ACS Sensors, 3(1), 54-58. doi:10.1021/acssensors.7b00735 2379-3694 https://hdl.handle.net/10356/139276 10.1021/acssensors.7b00735 29250951 2-s2.0-85041170726 1 3 54 58 en ACS Sensors © 2017 American Chemical Society. All rights reserved. |
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Engineering::Chemical engineering Keypad Lock Resettable Du, Yan Han, Xu Wang, Chenxu Li, Yunhui Li, Bingling Duan, Hongwei Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
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Recently, molecular keypad locks have received increasing attention. As a new subgroup of smart biosensors, they show great potential for protecting information as a molecular security data processor, rather than merely molecular recognition and quantitation. Herein, label-free electrochemically transduced Ag+ and cysteine (Cys) sensors were developed. A molecular keypad lock model with reset function was successfully realized based on the balanced interaction of metal ion with its nucleic acid and chemical ligands. The correct input of “1-2-3” (i.e., “Ag+-Cys-cDNA”) is the only password of such molecular keypad lock. Moreover, the resetting process of either correct or wrong input order could be easily made by Cys, buffer, and DI water treatment. Therefore, our system provides an even smarter system of molecular keypad lock, which could inhibit illegal access of unauthorized users, holding great promise in information protection at the molecular level. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Du, Yan Han, Xu Wang, Chenxu Li, Yunhui Li, Bingling Duan, Hongwei |
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Article |
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Du, Yan Han, Xu Wang, Chenxu Li, Yunhui Li, Bingling Duan, Hongwei |
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Du, Yan |
title |
Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
title_short |
Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
title_full |
Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
title_fullStr |
Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
title_full_unstemmed |
Smart sensing based on DNA – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
title_sort |
smart sensing based on dna – metal interaction enables a label-free and resettable security model of electrochemical molecular keypad lock |
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2020 |
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https://hdl.handle.net/10356/139276 |
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1681056144994336768 |